Pinyin: Zhi Mu  Chinese: 知母
Pharmaceutical: Rhizoma Anemarrhenae
Taxonomy: Anemarrhena asphodeloides
English: Anemarrhena Rhizome

Tastes: Bitter, sweet, cold
Meridians Entered: Lung, Stomach and Kidney

Actions & Indications:

1. Clears Heat and drains Fire (Clears Heat from the Qi Stage, from the Lungs and from the Stomach)
   Heat in the Qi Stage with high fever, irritability, restlessness, thirst and a rapid, flooding pulse.
   Lung Heat and Dryness with cough and expectoration of thick, yellow Phlegm
   Yang Ming Heat
   Stomach Heat
2. Nourishes Yin and moistens Dryness
   Lung and Kidney Yin Deficiency with night sweats, steaming bone disorder, irritability, afternoon or low grade fever, Five Sole Heat and bleeding gums
   (Stomach Yin Deficiency)
   Kidney Heat with spermatorrhea, nocturnal emissions and an abnormally elevated sex drive
3. Generates Fluids, clears Deficiency Fire and quenches thirst
   Oral ulcers and inflammation, steaming bones and Xiao Ke (diabetes) due to Yin Deficiency
4. Ameliorates the Dryness of tonifying or warming herbs
   For use with herbs such as Rx. Astragali Huang Qi, Ram. Cinnamomi Gui Zhi, Rx. Aconiti Lateralis Preparata Zhi Fu Zi when there is concern that these herbs may be too drying

Standard Dosage: 5-15g in decoction.
Cautions: It is not suitable for deficiency cold syndrome. Being cold and moist in property, it is prohibited to be used for those who have a spleen-deficiency diarrhea.

Pinyin: Dang Gui  Chinese: 當歸
Pharmaceutical: Radix Angelicae sinensis
Taxonomy: Angelica sinensis
English: Chinese Angelica Root / Tang-Kuei / Dong Quai Root

Tastes: Sweet, Pungent, Warm
Meridians Entered: Heart and Liver

Actions & Indications:

1. Tonifies the Blood and regulates the menses
   Blood Deficiency, especially when affecting the Heart and Liver with pale, ashen complexion, lusterless nails, tinnitus, blurred vision and palpitations
   Blood Deficiency associated irregular menstruation, amenorrhea and dysmenorrhea
2. Invigorates and harmonizes the Blood and disperses Cold (stops pain due to Blood Stasis)
   Blood Stasis causing abdominal pain and carbuncles and pain due to Blood Stasis from traumatic injury, especially when accompanied by Deficiency Cold
   Postpartum menstruation
   Pregnancy (use with caution)
   Blood Deficiency with chronic Wind-Damp-Bi
3. Moistens the Intestines and unblocks the bowels
   Dry Intestines due to Blood Deficiency
4. Reduces swelling, expels pus, generates flesh and alleviates pain
   Sores and abscess (Chuang Yung), internally and topically
5. Stops coughing and treats dyspnea
   Used adjunctively for coughing
6. Tonifies the Blood while suppressing Parasites
   Gu Sydnrome (Fruehauf, 1998)
   Chronic inflammatory disease (Fruehauf, 2015)

Standard Dosage: 6-12g in decoction.
Cautions: It is contraindicated in cases of Damp-Heat stagnating in the Middle, Lung Heat with Phlegm Fire, and Yin deficiency with effulgent Yang because it is warm and sweet in properties. In addition, it should be used with caution in cases of loose stool because it can moisten intestines to smooth stool.

Many sources recommend using caution, avoiding or only taking under guidance of a TCM physician during pregnancy as it can cause uterine contractions. However, there are no studies supporting this and the only scientific literature seems to suggest that Z-Ligustilide has anti-spasmodic activities that alleviate dysmenorrhoea by inhibiting uterine contractions (Du et al., 2006; Dietz et al., 2016).

Caution is also advised in breast cancer patients due to its oestrogen stimulating activity. This based upon Lau et al (2005) who found it may stimulate breast cancer growth in vitro, however Yue et al, (2019) demonstrated that it is not that stimulatory in breast cancer both in vitro and in vivo through a series of tests, although they suggested it should still be used with caution in estrogen receptor-positive breast cancer. Conversely, a large population study in Taiwan by Wu et al (2014) found it reduced the subsequent risk of endometrial cancer in breast cancer survivors taking tamoxifen, especially in those of reproductive age.

Pinyin: Sheng Di Huang  Chinese: 生地黃
Pharmaceutical: Radix Rehmanniae
Taxonomy: Rehmannia glutinosa
English: Chinese Foxglove Root / Rehmannia Root

Tastes: Sweet, bitter, cold
Meridians Entered: Heart, Liver, Stomach and Kidney

Actions & Indications:

1. Clears Heat and cools the Blood
   Ying Stage Heat with high fever, thirst and a scarlet tongue
   Xue Stage Heat
   Hemorrhage due to Blood Heat
2. Nourishes Yin, generates fluids, increases saliva and treats wasting and thirsting
   Yin Deficiency with Heat signs
   Injury to fluids
   Throat pain due to Yin Deficiency
   Wasting and thirsting disorder (消渴 Xiao Ke - diabetes)
3. Cools Heart Fire
   Heart Fire
4. Calms the Spirit agitated by Parasites damaging the Yin
   Gu Sydnrome (Fruehauf, 1998)
   Chronic inflammatory disease (Fruehauf, 2015)
5. Breaks up Blood Stasis, expels Cold and Hot Bi, replenishes Bone Marrow and promotes the growth of Muscles and Flesh
   Broken bones or severed sinews from falls and a damaged center (Shen Nong Ben Cao Jing)
6. Aids fasting
   Mentioned in the Shen Nong Ben Cao Jing as part of the superior class of herbs which can, with protracted taking, make the body light, and prevent forgetfulness. This may suggest it was part of supplementing the diet when engaging in an "avoiding grain" (Bigu 辟穀) fasting regime to cultivate life (Yangsheng 養生).

Standard Dosage: 10-15g in decoction.
Cautions: It is contraindicated in cases of diarrhea, abdomen distention due to spleen deficiency.

Pinyin: Da Huang  Chinese: 大黄
Pharmaceutical: Radix et Rhizoma Rhei
Taxonomy: Rheum palmatum
English: Chinese Rhubarb Root

Tastes: Bitter, cold
Meridians Entered: Large Intestine, Spleen, Stomach, Liver and Heart

Actions & Indications:

1. Drains Heat and purges accumulations
   Intestinal Heat Excess, with high fever, profuse sweating, thirst, constipation, abdominal distention and pain, delirium, a yellow tongue coat and a full pulse
   Yang-Ming Fu Stage
   Qi Level Heat in the Intestines
2. Drains Fire
   Fire from Excess with intense fever, sore throat, and painful eyes and constipation
   Fire toxin sores due to Xue Level Heat, especially with constipation
3. Clears Heat, transforms Dampness and promotes urination
   Damp-Heat with oedema, jaundice, painful urinary dysfunction and acute, hot dysenteric disorders
4. Drains Heat from the Blood
   Bloody stool either from hemorrhoids or Heat in the Intestines
   Chaotic movement of hot Blood with hemoptysis or epistaxis with constipation
   It can be powdered and administered orally for bleeding in the upper digestive tract
5. Invigorates the Blood and dispels Blood Stasis
   Blood Stasis with amenorrhea, fixed abdominal masses or fixed pain
   Blood Stasis due to traumatic injury
   Intestinal abscess
6. Clears Heat and reduces Fire toxicity
   Topically or internally for burns or skin lesions (Chuang Yung) due to Heat
7. Clears Heat and eliminates Phlegm
   Chronic Accumulation of Phlegm-Heat with cough, dyspnea, mania, disorientation and other symptoms of Phlegm Misting the Heart

Standard Dosage: 10-15g in decoction. Excessive decoction will reduce the purgative action. Therefore it should be added at end to achieve this purpose and over-decocted to eliminate this action.
Cautions: It should be used with caution in case of spleen and stomach deficiency for its bitter and cold property which is easily to damage stomach qi. It is contraindicated to women during pregnancy, menstruation or lactation for it has actions of activating blood and resolving stasis, and can make the purged substances follow lactating out.

Pinyin: Zhi Shi  Chinese: 枳实
Pharmaceutical: Fructus Aurantii Immaturus
Taxonomy: Citrus aurantium
English: Immature Seville Orange / Immature Bitter Orange / Immature Sour Orange

Tastes: Pungent, bitter, slightly cold
Meridians Entered: Spleen, Stomach and Large Intestine

Actions & Indications:

1. Breaks up Stagnant Qi, reduces accumulation, descends Qi, unblocks the bowels and removes Stagnant Food
   Qi Stagnation and accumulation with epigastric or abdominal pain and distention or indigestion with focal distention or gas
   Food Stagnation
2. Transforms Phlegm, reduces distention and resolves hardenings
   Turbid Phlegm Obstructing the Qi with focal distention and fullness in the chest and epigastrium

Standard Dosage: 3-10g in decoction.
Cautions: It should be used with cautions for pregnant women.

Pinyin: Hou Po  Chinese: 厚朴
Pharmaceutical: Cortex Magnoliae
Taxonomy: Magnolia officinalis
English: Magnolia Bark

Tastes: Bitter, pungent, warm
Meridians Entered: Spleen, Stomach, Lung and Large Intestine

Actions & Indications:

1. Promotes the movement of Qi in the Middle Jiao and resolves Stagnation
   Abdominal, epigastric, and/or chest fullness, bloating, loss of appetite, poor digestion, constipation
   Plum Pit Qi, a feeling of a lump in throat, usually considered psychosomatic today (globus hystericus). Hou Po has modern indications as neuroprotective and also features in formulas like Da/Xiao Cheng Qi Tang which deal with neuropsychiatric symptoms like delirium.
2. Promotes the movement of Qi downward, dries Dampness and transforms Phlegm
   Dampness or Phlegm Obstructing the Middle Jiao with distention, fullness, nausea and diarrhoea
3. Descends Rebellious Qi, reduces Phlegm and calms wheezing
   Cough and wheezing due to Phlegm congesting the Lungs
4. Removes the Three Worms
   Said in the Shen Nong Ben Cao Jing that it removes the Three Worms. These may refer to difficult to treat metabolic disorders caused by overindulgence and should be accompanied by fasting, meditation and exercise regimes.

Standard Dosage: 3-10g in decoction.
Cautions: It should be used with cautions for the syndrome of qi deficiency and fluid consumption, and in pregnant women. Due to some of the anticoagulant effects of its constituents it should be used with caution in conjunction with blood thinners.

Pinyin: Bai Shao  Chinese: 白芍
Pharmaceutical: Radix Paeoniae Alba
Taxonomy: Paeonia lactiflora
English: White Peony Root

Tastes: Bitter, sour, sweet, slightly cold
Meridians Entered: Spleen and Liver

Actions & Indications:

1. Nourishes the Blood and regulates menstruation
   Liver Blood Deficiency with menstrual dysfunction, vaginal discharge and uterine bleeding accompanied by a pale face, a lusterless complexion and dull, lusterless nails
   Anemia
   Breast distention and premenstrual syndrome
2. Astringes Yin and adjusts the Ying and Wei
   Yin Deficiency sweating Sweating due to Yin Collapse
   Disharmony between the Liver and Spleen
   Disharmony between the Ying and Wei with non-productive sweating
3. Calms Liver Yang and Liver Wind and alleviates pain
   Liver Qi Stagnation with Liver Yang Rising
   Liver Wind with Yin and Blood Deficiency
   Bi syndrome due to Blood Deficiency with pain and spasms
4. Softens the Liver and relieves pain
   Diarrhoea, borborygmus and abdominal pain
   Dysenteric disorders with tenesmus
5. Tonifies the Blood while suppressing Parasites
   Gu Sydnrome (Fruehauf, 1998)
   Chronic inflammatory disease (Fruehauf, 2015)

Standard Dosage: 10-30g in decoction.
Cautions: Caution with anticoagulants as it may slow clotting time. May also slow the absorption of phenytoin.