Pinyin: Zhu Sha  Chinese: 朱砂
Pharmaceutical: Cinnabaris
Taxonomy: HgS
English: Cinnabar / Vermilion / Mercury (II) Sulfide / 丹 Dan / 朱雀 Zhu Que (Red Raven)

Tastes: Sweet, cold, toxic
Meridians Entered: Heart

Actions & Indications:

1. Sedates the Heart and calms the Spirit
   Restlessness, palpitations, anxiety, insomnia and convulsions associated with a disturbed Spirit
   Heart Fire (with appropriate herbs)
   Phlegm Fire Disturbs the Heart (with appropriate herbs)
   Heart Blood Deficiency (with appropriate herbs)
2. Expels Phlegm and sedates jitteriness and convulsions while stopping tremors
   Seizures, childhood convulsions and other problems due to Phlegm-Heat Blocking the Pericardium and Heart
   Wind-Phlegm dizziness
   Lung Heat
3. Clears Heat, relieves toxicity and prevents putrefaction
   Topically for carbuncles, mouth sores, sore throat and snakebite
4. Aids fasting
   Mentioned in the Shen Nong Ben Cao Jing as part of the superior class of minerals which can, with protracted taking, enable one to communicate with the spirit light (Shenming) and prevent senility. This may suggest it was part of supplementing the diet when engaging in an "avoiding grain" (Bigu 辟穀) fasting regime to cultivate life (Yangsheng 養生) and spiritual practice.

Standard Dosage: No dosage is permissible due to mercury toxicity. 0.1-0.5g in powder or pills is traditional.
Cautions: Prohibited from use today due to its mercury content, it is generally omitted or substituted with Hu Po. Historically it was sometimes confused with Xue Jie, so this could also make a potential substitute in the right circumstances.

Zhao, Li & Wang (2022) claim that grinding and washing was a traditional method of removing the toxicity but any amount of mercury toxicity is unacceptable today.

Traditional contraindications include overdose and taking for a long period of time, or calcinification.

Pinyin: Huang Lian  Chinese: 黄连
Pharmaceutical: Rhizoma Coptidis
Taxonomy: Coptidis chinensis
English: Coptis Rhizome / Goldthread Rhizome

Tastes: Bitter, cold
Meridians Entered: Heart, Stomach, Large Intestine and Liver

Actions & Indications:

1. Clears Heat and drains Dampness
   Damp-Heat in the Stomach or Intestines with diarrhoea or dysenteric disorder
   Stomach Heat with vomiting and/or acid regurgitation
2. Drains Fire and resolves Fire toxicity
   Heat with Blazing Fire (Toxic Heat) with high fever. irritability, disorientation, delirium, a red tongue and a rapid, full pulse
   Heat from Excess with toxicity: painful, red eyes and a sore throat
   Boils, carbuncles and abscesses (Chuang Yung)
3. Clears Heat and stops bleeding
   Blood Heat with epistaxis, hematuria, hemafecia and hemoptysis
4. Clears Heat topically
   Infected wounds, red and painful eyes, ulcerations of the tongue and mouth (topical)
5. Clears Heart Fire (sedative)
   Heart Fire
   Lack of communication between the Heart and Kidneys
6. Drains Stomach Fire
   Stomach Fire
7. Aids fasting
   Mentioned in the Shen Nong Ben Cao Jing as part of the superior class of herbs which can, with protracted taking, improve memory. This may suggest it was part of supplementing the diet when engaging in an "avoiding grain" (Bigu 辟穀) fasting regime to cultivate life (Yangsheng 養生).

Standard Dosage: 2-10g in decoction.
Cautions: It is contraindicated for deficiency-cold syndrome. Because its taste is extremly bitter and dryness, overdosage and long-time taking will impair spleen and stomach, yin and fluids.

Pinyin: Dang Gui  Chinese: 當歸
Pharmaceutical: Radix Angelicae sinensis
Taxonomy: Angelica sinensis
English: Chinese Angelica Root / Tang-Kuei / Dong Quai Root

Tastes: Sweet, Pungent, Warm
Meridians Entered: Heart and Liver

Actions & Indications:

1. Tonifies the Blood and regulates the menses
   Blood Deficiency, especially when affecting the Heart and Liver with pale, ashen complexion, lusterless nails, tinnitus, blurred vision and palpitations
   Blood Deficiency associated irregular menstruation, amenorrhea and dysmenorrhea
2. Invigorates and harmonizes the Blood and disperses Cold (stops pain due to Blood Stasis)
   Blood Stasis causing abdominal pain and carbuncles and pain due to Blood Stasis from traumatic injury, especially when accompanied by Deficiency Cold
   Postpartum menstruation
   Pregnancy (use with caution)
   Blood Deficiency with chronic Wind-Damp-Bi
3. Moistens the Intestines and unblocks the bowels
   Dry Intestines due to Blood Deficiency
4. Reduces swelling, expels pus, generates flesh and alleviates pain
   Sores and abscess (Chuang Yung), internally and topically
5. Stops coughing and treats dyspnea
   Used adjunctively for coughing
6. Tonifies the Blood while suppressing Parasites
   Gu Sydnrome (Fruehauf, 1998)
   Chronic inflammatory disease (Fruehauf, 2015)

Standard Dosage: 6-12g in decoction.
Cautions: It is contraindicated in cases of Damp-Heat stagnating in the Middle, Lung Heat with Phlegm Fire, and Yin deficiency with effulgent Yang because it is warm and sweet in properties. In addition, it should be used with caution in cases of loose stool because it can moisten intestines to smooth stool.

Many sources recommend using caution, avoiding or only taking under guidance of a TCM physician during pregnancy as it can cause uterine contractions. However, there are no studies supporting this and the only scientific literature seems to suggest that Z-Ligustilide has anti-spasmodic activities that alleviate dysmenorrhoea by inhibiting uterine contractions (Du et al., 2006; Dietz et al., 2016).

Caution is also advised in breast cancer patients due to its oestrogen stimulating activity. This based upon Lau et al (2005) who found it may stimulate breast cancer growth in vitro, however Yue et al, (2019) demonstrated that it is not that stimulatory in breast cancer both in vitro and in vivo through a series of tests, although they suggested it should still be used with caution in estrogen receptor-positive breast cancer. Conversely, a large population study in Taiwan by Wu et al (2014) found it reduced the subsequent risk of endometrial cancer in breast cancer survivors taking tamoxifen, especially in those of reproductive age.

Pinyin: Sheng Di Huang  Chinese: 生地黃
Pharmaceutical: Radix Rehmanniae
Taxonomy: Rehmannia glutinosa
English: Chinese Foxglove Root / Rehmannia Root

Tastes: Sweet, bitter, cold
Meridians Entered: Heart, Liver, Stomach and Kidney

Actions & Indications:

1. Clears Heat and cools the Blood
   Ying Stage Heat with high fever, thirst and a scarlet tongue
   Xue Stage Heat
   Hemorrhage due to Blood Heat
2. Nourishes Yin, generates fluids, increases saliva and treats wasting and thirsting
   Yin Deficiency with Heat signs
   Injury to fluids
   Throat pain due to Yin Deficiency
   Wasting and thirsting disorder (消渴 Xiao Ke - diabetes)
3. Cools Heart Fire
   Heart Fire
4. Calms the Spirit agitated by Parasites damaging the Yin
   Gu Sydnrome (Fruehauf, 1998)
   Chronic inflammatory disease (Fruehauf, 2015)
5. Breaks up Blood Stasis, expels Cold and Hot Bi, replenishes Bone Marrow and promotes the growth of Muscles and Flesh
   Broken bones or severed sinews from falls and a damaged center (Shen Nong Ben Cao Jing)
6. Aids fasting
   Mentioned in the Shen Nong Ben Cao Jing as part of the superior class of herbs which can, with protracted taking, make the body light, and prevent forgetfulness. This may suggest it was part of supplementing the diet when engaging in an "avoiding grain" (Bigu 辟穀) fasting regime to cultivate life (Yangsheng 養生).

Standard Dosage: 10-15g in decoction.
Cautions: It is contraindicated in cases of diarrhea, abdomen distention due to spleen deficiency.

Pinyin: Gan Cao  Chinese: 甘草
Pharmaceutical: Radix Glycyrrhizae
Taxonomy: Glycyrrhiza uralensis seu glabra seu inflata
English: Liquorice Root

Tastes: Sweet, slightly cold
Meridians Entered: Heart, Lung and Spleen (and all 12 meridians)

Actions & Indications:

1. Tonifies the Spleen and augments Qi
   Spleen Qi Deficiency with shortness of breath, lassitude and loose stools
   Qi and Blood Deficiency with an irregular pulse and/or palpitations
   Heart Qi Deficiency or Heart Yang Deficiency
2. Moistens the Lungs, resolves Phlegm and stops coughing
   Lung Heat or Cold
   Productive or non-productive coughing
3. Moderates spasms and alleviates pain
   Painful muscle spasms of the abdomen and legs
4. Clears Heat and relieves Fire Toxicity
   Raw for Toxic Heat with sore throat or carbuncles and sores (Chuang Yung)
5. Antidote for many toxic substances (internal and topical)
   Poisoning
   Bites (after washing the wound, chew Gan Cao and apply a thick layer on the bite wound, changing whenever it dries out; Bao Xiang-Ao, 1846, New Compilation of Proven Formulas)
6. Moderates and harmonizes the harsh properties of other herbs and guides the herbs to all twelve channels
   Often added in small doses to harmonise formulas
7. Tonifies the Qi while suppressing Parasites
   Gu Sydnrome (Fruehauf, 1998)
   Chronic inflammatory disease (Fruehauf, 2015)
8. Aids fasting
   Mentioned in the Shen Nong Ben Cao Jing as part of the superior class of herbs which can, with protracted taking, make the body light and prolong life. This may suggest it was part of supplementing the diet when engaging in an "avoiding grain" (Bigu 辟穀) fasting regime to cultivate life (Yangsheng 養生).

Standard Dosage: Typically 1.5-9g in decoction. Large doses can be up 30g.
Cautions: It is contraindicated for combining with Hai Zao, Da Ji, Gan Sui and Yuan Hua because of "eighteen antagonisms". It is also contraindicated in cases of dampness obstruction in middle energizer and edema because it can help dampness obstruct qi, and it is prohibited from long-term usage in large dosage (more than 20g/day) and should be avoided or used with extreme caution in patients with high blood pressure because it may raise aldosterone levels in the blood causing retention of sodium.

The NHS recommends avoiding during pregnancy.